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Arginine/arginase NO NO NO.

Arginine is a semi-essential amino acid that plays a critical role in several metabolic pathways. The best known of these is as the immediate precursor of urea in the liver and to a lesser extent in the intestine.1 The enzyme responsible for the cleavage of arginine to produce urea is arginase, which is the only enzyme in the urea cycle that comes in two forms, arginase I, a cytosolic enzyme, a...

بررسی سطح انرژی پتانسیل بین مولکولی سامانه no-no

برای بررسی انرژی برهم کنش بین مولکولی سامانه no-no محاسبات با روش همبستگی ump2،b3lyp و qsisd(t) با استفاده از مجموعه های همبستگی سازگار دانینگ، cc-pvdz و cc-pvtz و همچنین تکمیل شده دو مجموعه، با افزایش توابع پخش aug-cc-pvdz وaug-cc-pvtz و مجموعه پایه6-311+g و تکمیل شده مجموعه با افزایش توابع نفوذی 6-311+g* انجام گرفته است. با هر یک از روش‎ها و مجموعه های پایه ذکر شده، چهار حالت مختلف و 37 مقد...

“No Water, No Life. No Blue, No Green”

W is the most precious and essential natural resource. If unadulterated and at room temperature, it is tasteless, odorless (to humans), and transparent. Water sustains life, reshapes topography, provides passage and conveyance, and delineates and destroys geopolitical boundaries. Water comprises ≈71% of Earth’s surface, and the United States Geological Survey estimates that Earth is covered by ...

No scrubs. No shoes. No serving.

the Ottawa Hospital has introduced a dress code that will require staff to wear uniforms prescribed by their respective departments and functions. The Ontario-based hospital may be the first to issue a formal, publicized dress code in the country. Put into effect in March, the code requires staff to don their scrubs and lab coats whenever they enter the hospital, and take them off when they lea...

No vehicle, no problem

In the last 8 years the field of microRNA (miRNA) replacement therapeutics has generated a lot of interest and at the same time skepticism due to failures. The therapeutic prospect is to use small synthetic RNA molecules that mimic endogenous miRNAs to restore the miRNA levels in cells that have lost them with the final goal of modulating cellular pathways that drive pathogenesis. However, as w...

No gag, no food.

No Foundations, No Edifice:

This essay is a response to the article published in International Organization (2001) by George Tsebelis and Geoffrey Garrett. The article grossly misrepresented the state of current theoretical and empirical work on European integration, including some of our own arguments. Believing that such distortions damage scholarly discourse, we requested that IO publish a response detailing, and corre...